Intravenous infusion of nicotinamide adenine dinucleotide (NAD+) delivered in saline to temporarily raise circulating NAD+ levels; marketed for energy, focus, and recovery. Evidence for specific clinical outcomes remains limited in humans; safety appears acceptable in short-term studies when administered properly.
NAD+ IV Therapy (often listed as “NAD+ drip”) infuses nicotinamide adenine dinucleotide directly into circulation to acutely augment the cellular NAD+ pool. NAD+ is central to mitochondrial ATP production and serves as a substrate for sirtuins and PARPs—enzymes that regulate DNA repair, stress responses, and inflammation. Age and chronic inflammation reduce NAD+ via increased consumption (PARP/CD38) and reduced synthesis; IV delivery aims for rapid augmentation when GI absorption or tolerance to oral precursors is limiting.
How It’s Used
Typical protocols infuse 250–750 mg diluted in saline over 60–180 minutes (rate adjusted to comfort to minimize chest pressure, flushing, or nausea). Programs often include a loading phase (e.g., 4–6 sessions over 1–2 weeks) followed by monthly maintenance, paired with oral precursors (NR/NMN) and mitochondrial cofactors (magnesium, riboflavin) to sustain intracellular pools.
Evidence Positioning
Human randomized trials consistently show that oral precursors like nicotinamide riboside (NR) elevate blood NAD+ and can impact selected cardiometabolic and inflammatory markers in older adults. Direct clinical evidence for IV NAD+ is more limited (primarily pharmacokinetic/observational). Present IV NAD+ as an adjunct within a comprehensive program—sleep, exercise, and glycemic control all influence NAD+ turnover and downstream benefits.
Safety
When compounded from USP-grade ingredients and administered by trained staff, adverse effects are usually rate-related and transient (warmth, chest pressure, lightheadedness). Screen for arrhythmias, active peptic disease, severe liver disease, and migraine sensitivity. Maintain hydration; document lot numbers and infusion parameters.
Integration & Outcomes
Combine with circadian alignment, resistance/aerobic training, and nutrition to translate biochemical changes into functional outcomes. Track fatigue, HRV, cognitive measures, and activity output; favor behaviors that sustain NAD+ economy between infusions.
Summary
NAD+ IV Therapy is on-demand mitochondrial support—useful for rapid augmentation, best sustained by lifestyle and micronutrient strategies that maintain cellular NAD+ balance.
Hydrate well; eat a light meal beforehand; wear comfortable clothing; bring a snack/water; disclose all medications and supplements.
Minimal downtime; mild fatigue, headache, or nausea may occur the day of infusion—usually relieved by rate adjustment, rest, and hydration.
Most common: flushing/warmth, nausea, headache, dizziness/lightheadedness during infusion; typically transient and dose- or rate-related. Serious adverse events are rare in published reports of short-term use. Use sterile, pharmaceutical-grade ingredients only.
Trammell S.A.J. et al. Nicotinamide Riboside Increases NAD+ in Humans (Nat Commun, 2016).
https://doi.org/10.1038/ncomms12948Martens C.R. et al. Chronic NR Supplementation in Older Adults: Cardiometabolic Effects (Nat Commun, 2018).
https://doi.org/10.1038/s41467-018-03421-7Yoshino J., Baur J.A., Imai S. NAD+ Intermediates—Biology & Therapeutic Potential (Cell Metab, 2018).
https://doi.org/10.1016/j.cmet.2018.08.001Rajman L., Chwalek K., Sinclair D.A. Therapeutic Potential of NAD+ Boosting (Cell Metab, 2018).
https://doi.org/10.1016/j.cmet.2018.01.008Lautrup S., Sinclair D.A., Mattson M.P., Fang E.F. NAD+ in Brain Aging & Neurodegeneration (Nat Rev Neurol, 2019).
https://doi.org/10.1038/s41582-019-0182-9© 2026 Longevity Clinic Finder. All rights reserved.
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Frequency
Common clinic practice: weekly x4 → biweekly x2–4 → monthly maintenance; individualized.
Adults seeking wellness support (energy/fatigue, recovery, travel) who understand benefits are not conclusively proven and are willing to pay out-of-pocket.
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