An invasive, continuous extracorporeal blood procedure in which blood is circulated through a circuit for oxygen–ozone exposure and processing before return. Distinct from limited-volume major autohemotherapy, not FDA-approved to treat disease, and typically cash-pay.
Extracorporeal Blood Oxygenation and Ozonation (EBOO) circulates blood continuously outside the body through a treatment circuit before returning it to the patient. Clinics may combine oxygen–ozone exposure with a filter or other processing and describe the setup as “ozone dialysis.” EBOO processes a larger blood volume than major autohemotherapy (MAH), which draws and treats a limited amount in a container and then reinfuses it.
What it is not
EBOO is not hemodialysis for kidney failure, not ECMO, and not a proven blood detoxification procedure. It is not FDA-approved to prevent or treat disease in the United States. Device configurations and protocols vary, so the acronym does not describe one standardized intervention.
Evidence and claims
Clinics market EBOO for chronic infection, inflammation, cardiovascular disease, autoimmune conditions, long COVID, and anti-aging. High-quality clinical outcome evidence is insufficient for these broad claims. Removing discoloration from a filter or changing blood appearance is not proof that toxins, microplastics, or pathogens were clinically removed.
Safety
EBOO requires large-bore venous access, an extracorporeal circuit, anticoagulation in many protocols, sterile technique, air detection, and emergency capability. Risks include bleeding, infection, thrombosis, hemolysis, hypotension, electrolyte or anticoagulant complications, air/gas embolism, and line failure. Ozone gas must not be injected directly into a vein or inhaled.
Bring medication and anticoagulant lists, recent blood count and kidney/liver results when requested, and arrange transportation if the clinic recommends it. Eat and hydrate as directed. Ask exactly which device and circuit are used.
Rest and hydrate. Fatigue, bruising, or lightheadedness can occur. Seek urgent care for chest pain, shortness of breath, neurologic symptoms, uncontrolled bleeding, fever, or worsening access-site swelling.
Bleeding, infection, thrombosis, hemolysis, hypotension, anticoagulant or citrate effects, electrolyte changes, vascular-access injury, air/gas embolism, circuit failure, and delayed evidence-based care. The procedure is more invasive than MAH.
21 CFR § 801.415. Maximum acceptable level of ozone.
https://www.ecfr.gov/current/title-21/chapter-I/subchapter-H/part-801/subpart-H/section-801.415U.S. EPA. Health effects of ozone pollution.
https://www.epa.gov/ground-level-ozone-pollution/health-effects-ozone-pollutionCDC. Injection Safety.
https://www.cdc.gov/injection-safety/© 2026 Longevity Clinic Finder. All rights reserved.
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Adults considering an investigational elective procedure who have been medically screened and understand the evidence limitations, cost, and extracorporeal-circuit risks. Not a replacement for dialysis, antimicrobial therapy, cancer treatment, or cardiovascular care.
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