Longevity Treatment Guides

Choose licensed clinicians who confirm an indication, order the right labs, screen for VTE and breast-cancer history, and monitor—not pellet mills that skip contraindications.

FDA-approved hormones are preferred when a labeled product fits. Compounded BHRT is not automatically more natural or safer. ACOG and NAMS caution against routine custom mixes.

Bioidentical is a chemistry claim, not a safety guarantee. Approved estradiol and progesterone are already bioidentical. Compounded BHRT is not automatically better.

Women's hormone health is complex and changes throughout life. Explore evidence-based longevity treatments for optimizing hormones, managing menopause, and supporting women's health at every stage.

Testosterone for men whose fatigue and low libido come with confirmed hypogonadism. It will not fix sleep apnea, depression, or a normal testosterone. Hematocrit, PSA as indicated, and fertility plans are part of the deal.

Menopausal hormone therapy for hot flashes, night sweats, sleep disruption, and genitourinary symptoms. Best evidence is for bothersome symptoms, especially when started nearer to menopause. Not a default anti-aging prescription.

Prescription testosterone for men with confirmed hypogonadism. Injections, gels, and pellets are common in longevity clinics. It suppresses sperm production, can raise hematocrit, and is not a wellness tonic for a normal testosterone level.

Estradiol (or other estrogen) for menopausal symptoms, genitourinary syndrome, and selected bone indications. If the uterus is present, a progestogen is required for endometrial protection. Transdermal routes are often preferred over oral conjugated estrogen.

A map of how sex hormones are actually delivered: patch, gel, oral, vaginal, injection, and pellet. Route changes clotting risk, convenience, and how fast you can stop—often more than the word bioidentical does.

Small subcutaneous implants of testosterone and/or estradiol, usually compounded, inserted in the hip or buttock every few months. Convenient and hard to reverse if levels run high. Not first-line in major society guidelines.

Medical replacement of sex hormones—chiefly estradiol, progesterone, and testosterone—when deficiency causes symptoms or disease risk. Includes FDA-approved products and, in some clinics, compounded bioidenticals. Not a longevity drug and not the same as thyroid or peptide protocols.

Micronized progesterone (and, separately, synthetic progestins) used with estrogen to protect the endometrium, and sometimes for sleep. Prometrium-type progesterone is not the same molecule as medroxyprogesterone acetate used in WHI.

Customized use of bioidentical hormones (e.g., estrogen, progesterone, testosterone, DHEA) compounded or FDA-approved to address symptoms of hormone decline, such as menopause, andropause, or adrenal insufficiency. Delivered via creams, gels, troches, injections, or pellets, under medical supervision.